Long COVID · ME/CFS · POTS · Autoimmune

When Every Test Comes Back “Normal” — But You Know Something Is Wrong

A blood test that maps your immune system's antibody-producing cells to find if they're attacking your own body — and helps your doctor understand whether B-cell-targeted therapies may be worth exploring.

You've been told your labs are “fine.” Your symptoms are real.

Standard blood tests look at a few specific antibodies. If those are negative, you're told nothing is wrong. But your immune system has millions of antibody-producing cells — and standard tests only check a handful of them.

Clono looks at the full picture. We sequence the genetic code of your B-cells — the cells that make antibodies — to find patterns that standard tests completely miss. Including antibodies that may be attacking your own nerves, joints, or organs.

How It Works

From a Simple Blood Draw to Real Answers

1

Simple Blood Draw

A single tube of blood, just like a routine lab test. Collected at your doctor's office or at home with a collection kit.

2

Deep Immune Mapping

We read the genetic code of your B-cells to create a complete map of your antibody-producing immune cells — far more detailed than any standard test.

3

AI-Powered Analysis

Advanced AI compares your immune map against known disease patterns to find antibodies that shouldn't be there — ones that may be attacking your own body.

4

Your Personalized Report

A clear, actionable report for you and your doctor: what we found, what it means, and information to help your doctor understand whether B-cell-targeted approaches may be worth exploring.

What You'll Learn

The Answers Other Tests Can't Give You

Is my immune system producing self-attacking antibodies?

We detect expanded groups of B-cells that are producing antibodies similar to known autoimmune patterns — even when standard tests like ANA come back negative.

Which parts of my body are being targeted?

Our analysis identifies which specific body systems the antibodies may be attacking — nerves (autonomic, peripheral), joints, connective tissue, or other organs.

Could B-cell-targeted therapies be worth exploring?

If we find active B-cell-driven autoimmunity, results help your doctor understand whether B-cell-targeted therapies may be worth considering — and which questions to ask. We don't prescribe treatments; your doctor makes all treatment decisions based on the full clinical picture.

Is my treatment actually working?

Re-testing after treatment shows whether the problematic B-cell clones are gone, shrinking, or coming back — like a progress report for your immune system.

Credibility

Developed by Stanford researchers

Clono was built by postdocs in immunology and digital health at Stanford University, with deep expertise in B-cell biology, repertoire analysis, and translational biomarker development.

Stanford University

Questions

Frequently Asked Questions

How is this different from an ANA test?

An ANA test checks for one type of antibody against cell nuclei. It's a yes/no screening test. Clono sequences the genetic code of all your B-cells to find any and all self-attacking antibody patterns — including ones ANA tests never look for. Many autoimmune conditions are ANA-negative but still driven by pathogenic B-cells.

Will my doctor know what to do with the results?

Yes. The report is designed for clinicians. It includes specific findings, clinical implications, and suggested next steps. We also provide clinician support materials and are available to consult with your doctor about the results.

How much does it cost?

We're finalizing pricing for patient access. Join the waitlist to be notified when ordering opens and to receive early-access pricing information.

Do I need a doctor's order?

Currently, yes — the test is ordered through a healthcare provider. If you don't have a provider familiar with this type of testing, we can help connect you with one.

How long until I get results?

Results are typically available 2–3 weeks after the lab receives your sample. You and your doctor will be notified when your report is ready.

Want to dive deeper into the science? Read about our methodology

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Get Notified When the Test Is Available

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