
A blood test that maps your immune system's antibody-producing cells to find if they're attacking your own body — and helps your doctor understand whether B-cell-targeted therapies may be worth exploring.
Standard blood tests look at a few specific antibodies. If those are negative, you're told nothing is wrong. But your immune system has millions of antibody-producing cells — and standard tests only check a handful of them.
Clono looks at the full picture. We sequence the genetic code of your B-cells — the cells that make antibodies — to find patterns that standard tests completely miss. Including antibodies that may be attacking your own nerves, joints, or organs.
How It Works
A single tube of blood, just like a routine lab test. Collected at your doctor's office or at home with a collection kit.
We read the genetic code of your B-cells to create a complete map of your antibody-producing immune cells — far more detailed than any standard test.
Advanced AI compares your immune map against known disease patterns to find antibodies that shouldn't be there — ones that may be attacking your own body.
A clear, actionable report for you and your doctor: what we found, what it means, and information to help your doctor understand whether B-cell-targeted approaches may be worth exploring.
What You'll Learn
We detect expanded groups of B-cells that are producing antibodies similar to known autoimmune patterns — even when standard tests like ANA come back negative.
Our analysis identifies which specific body systems the antibodies may be attacking — nerves (autonomic, peripheral), joints, connective tissue, or other organs.
If we find active B-cell-driven autoimmunity, results help your doctor understand whether B-cell-targeted therapies may be worth considering — and which questions to ask. We don't prescribe treatments; your doctor makes all treatment decisions based on the full clinical picture.
Re-testing after treatment shows whether the problematic B-cell clones are gone, shrinking, or coming back — like a progress report for your immune system.
Credibility
Clono was built by postdocs in immunology and digital health at Stanford University, with deep expertise in B-cell biology, repertoire analysis, and translational biomarker development.

Questions
An ANA test checks for one type of antibody against cell nuclei. It's a yes/no screening test. Clono sequences the genetic code of all your B-cells to find any and all self-attacking antibody patterns — including ones ANA tests never look for. Many autoimmune conditions are ANA-negative but still driven by pathogenic B-cells.
Yes. The report is designed for clinicians. It includes specific findings, clinical implications, and suggested next steps. We also provide clinician support materials and are available to consult with your doctor about the results.
We're finalizing pricing for patient access. Join the waitlist to be notified when ordering opens and to receive early-access pricing information.
Currently, yes — the test is ordered through a healthcare provider. If you don't have a provider familiar with this type of testing, we can help connect you with one.
Results are typically available 2–3 weeks after the lab receives your sample. You and your doctor will be notified when your report is ready.
Want to dive deeper into the science? Read about our methodology
Stay Updated
We're working to make this available as soon as possible. Leave your details and we'll let you know when you can get tested.